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LGD-4033 is a selective androgen receptor modulator (SARM) that usually binds to the androgen receptor with high affinity and selectivity. It demonstrates anabolic activity in muscles, anti-resorptive and anabolic activity in bones and a robust selectivity for muscle and bone versus prostate and sebaceous glands. LGD-4033 is the most potent and the most selective oral SARM that has been developed to date.
LGD-4033, a member of a class of compounds called SARMS or selective androgen receptor modulators, is currently under investigation as a potential male hormonal contraceptive. LGD-4033 is an orally active nonsteroidal SARM that binds to androgen receptors with high affinity and selectivity. LGD-4033 demonstrates anabolic activity in muscles, anti-resorptive and anabolic activity in bones and a robust selectivity for muscle and bone versus prostate and sebaceous glands.
LGD-4033 has been shown to increase lean body mass, reduce fat mass and increase bone density in non-human primates.
LGD-4033 | |
CAS Number | 1165910-22-4 |
Molar Mass | 338.253 g·mol−1 |
Chemical Formula | C14H12F6N2O |
IUPAC Name | 4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile |
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