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The study found that mice with low levels of myostatin have twice the amount of muscle mass compared to mice with high levels of myostatin. This shows the massive potential research implications of the strong anabolic effects that YK-11 can possess.
GW-501516, also known as Cardarine, is a PPAR agonist. Cardarine is used in research for its potential to facilitate fat-burning by increasing endurance and stamina. A study done on the effects of GW-501516 for enhancing running endurance in Kunming mice demonstrated that a 3-week dosing protocol with GW501516 was able to increase performance related to running of both trained and untrained mice. Similar to training, GW501516 showed an increase in mitochondrial fatty acid oxidation and enhanced fat metabolism in muscle tissue.
This could potentially lead to less demanding cardiovascular work, increasing weekly deficits, resulting in increased fat loss. A recent study set out to investigate the effects of MK-677 as a Ghrelin mimetic on body composition and clinical outcomes in healthy older adults. It was found that MK-677 enhanced fluctuating growth hormone secretion and markedly increased fat free mass over a 12-month period.
YK-11 | |
CAS Number | 1370003-76-1 |
Molar Mass | 430.541 g·mol−1 |
Chemical Formula | C25H34O6 |
IUPAC Name | methyl (2E)-2-[(8R,9S,10R,13S,14S,17S)-2′-methoxy-2′,13-dimethyl-3-oxospiro[1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-17,5′-1,3-dioxolane]-4′-ylidene]acetate |
Cardarine | |
CAS Number | 317318-70-0 |
Molar Mass | 453.49 g·mol−1 |
Chemical Formula | C21H18F3NO3S2 |
IUPAC Name | 4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]-2-methylphenoxy}acetic acid |
MK677 | |
CAS Number | 159634-47-6 |
Molar Mass | 528.67 g·mol−1 |
Chemical Formula | C14H12F6N2O |
IUPAC Name | 2-amino-2-methyl-N-[1-(1-methylsulfonylspiro[2H indole-3,4′-piperidine]-1′-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propenamide |
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